Pregnancy Alters Platelet Counts and Enhances Platelet Reactivity in Mice
نویسندگان
چکیده
منابع مشابه
Platelet-associated tissue factor enhances platelet reactivity and thrombin generation in experimental studies in vitro.
INTRODUCTION The thrombogenic potential of tissue factor (TF) associated to platelets is controversial. We have investigated the in vitro contribution of platelet-associated TF to thrombus formation. MATERIALS AND METHODS Platelets suspensions were exposed to human TF-rich microvesicles (TF-MV) from placental or recombinant origin. Platelet-associated TF was quantified through coagulometric a...
متن کاملPlatelet Counts and Platelet Activation Markers in Obese Subjects
OBJECTIVE In this work we studied the correlation between platelet count, platelet activation, and systemic inflammation in overweight, obese, and morbidly obese individuals. METHODS AND SUBJECTS A total of 6319 individuals participated in the study. Complete blood counts, high sensitivity C-reactive protein (hs-CRP) serum levels, and body mass index (BMI) were measured during routine checkup...
متن کاملFlavanols and Platelet Reactivity
Platelet activity and platelet-endothelial cell interactions are important in the acute development of thrombosis, as well as in the pathogenesis of cardiovascular disease. An increasing number of foods have been reported to have platelet-inhibitory actions, and research with a number of flavanol-rich foods, including, grape juice, cocoa and chocolate, suggests that these foods may provide some...
متن کاملCoronary angioplasty enhances platelet reactivity through von Willebrand factor release.
Shear induced platelet activation is responsible for arterial thrombosis. The role of fibrinogen is established at low shear stress, but at high shear stress von Willebrand factor (vWF), not fibrinogen, is essential for platelet adhesion and aggregation. Patients with vWF deficiency exhibit resistance to thrombosis, and raised vWF is a risk factor for acute coronary syndromes. Interpretation of...
متن کاملPlatelet counts and its course for predicting in-hospital mortality in intensive care unit
Background & Aims: Recent studies have shown that thrombocytopenia (TP) is associated with poor outcomes in patients with pneumonia, burns, and H1N1 influenza. The aim of this study is to determine the impact of platelet count trends and TP on mortality in intensive care unit (ICU) patients. Materials & Methods: TP was defined as <150,000 platelets/ml. In this study, 300 patients who had been ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 2020
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2020-143243